Steroids and derivatives
Medchemexpress LLC N-(1-phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine | 662164-09-2 | MFCD04077665 | 99.5% | 333.43 | C20H23N5 | 10MM 1ML
D3-βArr is a small-molecule positive allosteric modulator of the thyrotropin receptor intended for research use. It is supplied as a solid and as a 10 mM solution in DMSO, and is used in receptor pharmacology and functional assays to study β-arrestin translocation and TSHR signaling.
- Positive allosteric modulator of the thyrotropin receptor (TSHR).
- Supports beta-arrestin translocation and TSHR functional assays.
- High purity (reported ~99.5%).
- Available as solid (multiple mg sizes) and 10 mM solution in DMSO.
- Molecular formula C20H23N5, molecular weight 333.43.
Medchemexpress LLC (S)-N-((3-Methyl-1-(methyl-d3)-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide | 2216712-66-0 | 99.23% | 600.67 | 500 UG
Elexacaftor-d3 (VX-445-d3) is the deuterium labeled form of Elexacaftor, designed as a tracer and internal standard for quantitative analysis using methods like NMR, GC-MS, or LC-MS. Deuterium substitution can impact the pharmacokinetic and metabolic profiles of drugs. Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, which helps restore Phe508del CFTR protein function and has potential in treating cystic fibrosis. When combined with Tezacaftor and VX-770, it significantly enhances Phe508del CFTR protein processing, trafficking, and chloride transport.
- Tracer and internal standard for quantitative analysis
- Potential to influence pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Potential to treat cystic fibrosis
- Enhances CFTR protein processing, trafficking, and chloride transport
Medchemexpress LLC Cyclin D2/CCND2 Antibody (YA789) | Predicted band size: 33 kDa; Observed band size: 38 kDa | 100 UL
The Cyclin D2/CCND2 Antibody (YA789) is a Mouse-derived, non-conjugated IgG2b monoclonal antibody designed to target Cyclin D2/CCND2. It is suitable for use in Western Blot (WB) applications.
- Mouse-derived
- Monoclonal antibody
- Reacts with human samples
- Supplied in 1x PBS, 50% glycerol, 0.5% BSA, and 0.02% sodium azide
- Recommended storage at -20°C for up to one year
- Affinity purified
- Non-conjugated
- Isotype IgG2b
Sigma Aldrich Fine Chemicals Biosciences 2 Keto 3 methyl d3 butyrc500MG
2 Keto 3 methyl d3 butyrc500MG
[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCCN(C)C | 5mg | 779524214](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502467785.JPG-250.jpg)
eMolecules 184582-91-0 | DMPAC-Chol | Broadpharm514.839 | C33H58N2O2 | 0.000 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCCN(C)C | 5mg | 779524214
DMPAC-Chol | Broadpharm | 184582-91-0514.839 | C33H58N2O2 | 0.000 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCCN(C)C | 5mg | 779524214
Medchemexpress LLC N-Caproicacid-d3 so 5mg
N-caproicacidsodiumsalt-d3 is the deuterium labeled N-caproicacidsodiumsalt[1]
Medchemexpress LLC Dopamine D2 receptor antagonist-1 | 1055411-77-2 | 99.1% | 1 ML
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity.
- Acts as a negative allosteric modulator
- Targets the dopamine D2 receptor (D2R)
- Exhibits sub-mM affinity
Cayman Chemical 6-MethylmercaptopurIn-d3 10mg
An internal standard for the quantification of 6-MMP by GC- or LC-MS
eMolecules 6147-11-1 | ??-mangostin | Ambeed | MFCD00135200 | 410.466 | C24H26O6 | 98.000 | COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C | 1mg | 761012452
??-mangostin | Ambeed | 6147-11-1 | MFCD00135200 | 410.466 | C24H26O6 | 98.000 | COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C | 1mg | 761012452
Cayman Chemical 4-hydroxy Nonal-d3 1mg
An internal standard for the quantification of 4-HNE by GC- or LC-MS
Medchemexpress LLC Palonosetron-d3 hydrochloride | 1246816-81-8 | C19H22D3ClN2O | 1 MG
Palonosetron-d3 hydrochloride is the deuterium-labeled Palonosetron hydrochloride. Palonosetron hydrochloride acts as a 5-HT3 antagonist, primarily utilized for the prevention of acute, delayed, and overall chemotherapy-induced nausea and vomiting. Additionally, it exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also has antidepressant activity.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
eMolecules 7575-93-1 | Methyl-d3 4-Methylbenzenesulfonate | Accela ChemBio (ASD) | MFCD00008417 | 186.230 | C8H10O3S | 98.000 | COS(=O)(=O)c1ccc(C)cc1 | 5g | 536763903
Methyl-d3 4-Methylbenzenesulfonate | Accela ChemBio (ASD) | 7575-93-1 | MFCD00008417 | 186.230 | C8H10O3S | 98.000 | COS(=O)(=O)c1ccc(C)cc1 | 5g | 536763903
Medchemexpress LLC Dopamine D2 receptor agonist-3 | 1257326-24-1 | 98.3% | 295.81 g/mol | C15H22ClN3O | 25 MG
Dopamine D2 receptor agonist-3 is a research compound characterized as a selective D2 receptor partial agonist and a D3 receptor antagonist. In vitro activity is reported with pEC50 8.3 at D2 and <5.5 at D3. In vivo, a 3 mg/kg (s.c.) dose demonstrated high brain penetration (brain:blood ratio ≈5.5) with Tmax ≈0.5 h. The compound is a solid with reported purity of 98.3% and molecular formula C15H22ClN3O.
- Selective D2 receptor partial agonist and D3 receptor antagonist.
- Reported pEC50 values: 8.3 (D2) and <5.5 (D3).
- High reported purity (98.3%).
- Solid form, suitable for research applications.
- Demonstrated brain penetration in vivo (3 mg/kg, s.c.; brain:blood ratio ~5.5).
- Available in small pack sizes, including 25 mg.